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circRNA研究汇总 | 20210607-0614
来源: | 作者:geneseed | 发布时间: 2021-06-15 | 277 次浏览 | 分享到:

欢迎各位来到“circRNA研究报道汇总”栏目,本期从pubmed中检索收集最新发布的circRNA文献共计71篇,下面我们一起来看看,circRNA研究最近有哪些新进展。

检索式:(circRNA[Title/Abstract]) OR Circular RNA[Title/Abstract]

 

1、

标题:Circular RNA circHIPK3 promotes homeostasis of the intestinal epithelium by reducing miR-29b function

杂志:Gastroenterology. 影响因子:17.373

通讯作者:汪建英教授(马里兰大学医学院

环状RNAcircRNA)是一类形成共价闭合环的内源性非编码RNA。尽管 circRNA 影响许多生物过程,但对其在肠上皮稳态中的作用知之甚少。我们调查了维持肠上皮完整性所需的 circRNA,并确定 circHIPK3 是急性损伤后肠上皮修复的主要调节因子。方法:从暴露于盲肠结扎穿孔(CLP48 小时的小鼠和患有炎症性肠病(IBD)和败血症的患者中收集肠粘膜组织。我们从小鼠的小肠中分离出原代肠上皮细胞并衍生出肠道类器官。通过转染靶向circHIPK3环化位点 siRNA 或使用过表达 circHIPK3 ,在体外损伤模型中检查肠上皮修复。 circHIPK3miR-29b的关联通过生物素标记的RNA pulldown 测定。结果表明:全基因组图谱分析确定了大约 300 个相对于假手术组小鼠,在 CLP小鼠的肠粘膜中差异表达 circRNA,包括 circHIPK3IBD和败血症患者的肠黏膜 circHIPK3 水平降低。增加 circHIPK3 水平可增强受伤后肠上皮修复,而circHIPK3沉默抑制上皮恢复。 circHIPK3沉默还抑制了IECs和肠道类器官的生长,circHIPK3过表达促进了小鼠肠道上皮的更新。机制研究表明,circHIPK3 直接与 miR-29b 结合并抑制 miR-29 活性,从而增加受伤后 IEC Rac1Cdc42 和细胞周期蛋白 B1 的表达。在对小鼠、IEC 和人体组织的研究中,我们的结果表明 circHIPK3 至少部分通过降低 miR-29b 的可用性来改善肠上皮的修复。

 

2、circACTN4FUBP1相互作用通过调节原癌基因MYC的表达促进乳腺癌的发生和进展

标题:The circACTN4 interacts with FUBP1 to promote tumorigenesis and progression of breast cancer by regulating the expression of proto-oncogene MYC

杂志:Mol Cancer. 影响因子:15.303

通讯作者:陈俊霞教授(重庆医科大学

最近的研究表明,环状RNAcircRNA)在包括乳腺癌(BC)在内的多种癌症的发生和发展中发挥着重要作用。然而,大多数circRNA的潜在功能和BC进展的分子机制仍然难以捉摸。该研究中Circular RNA 微阵列技术检测4对乳腺癌组织和癌旁组织。通过qRT-PCR和原位杂交确定circACTN4BC细胞和组织中的表达和预后意义。实施功能获得和失实验以观察circACTN4对体外和体内BC细胞生长、侵袭和转移的影响。在机制上,进行了染色质免疫沉淀、荧光素酶报告基因、RNA pulldown、质谱、RNA 免疫沉淀、荧光原位杂交和免疫共沉淀分析。结果显示:CircACTN4 在乳腺癌组织和细胞中显著上调,其表达与 BC 患者的临床分期和不良预后相关。 circACTN4的异位表达显著促进了体外和体内乳腺癌细胞的生长、侵袭和转移。而敲 circACTN4 则显示出相反的作用。 CircACTN4 主要分布在细胞核中。进一步的机制研究证明,circACTN4可以与远上游元件结合蛋白1FUBP1)竞争性结合,阻止FUBP1FIR结合,从而激活MYC转录,促进乳腺癌的肿瘤进展。此外,我们发现上游转录因子 2USF2)可能促进 circACTN4 的生物发生。我们的研究结果揭示了一个关键机制,即USF2介导的circACTN4可能与FUBP1相互作用,通过增强MYC的表达促进乳腺癌的发生和发展。 CircACTN4 可能成为诊断和治疗乳腺癌的新潜在靶点。文献解读请点击:CircACTN4促进乳腺癌发生发展的机制研究

 

3、硫化氢暴露通过circRNA-17828/miR-6631-5p/DUSP6串扰调节ROS产生诱导肉鸡气管焦亡

标题:Hydrogen sulfide exposure induces pyroptosis in the trachea of broilers via the regulatory effect of circRNA-17828/miR-6631-5p/DUSP6 crosstalk on ROS production

杂志:J Hazard Mater. 影响因子:9.036

通讯作者:ShuLi和徐世文教授(东北农业大学)

硫化氢 (H2S) 是一种空气污染物,会导致气管损伤。细胞焦亡是通过产生活性氧 (ROS) 造成组织损伤的原因。竞争性内源性 RNA (ceRNAs) 吸附 microRNAs 并降低它们对其他转录物的抑制作用,从而影响 ROS 水平和细胞焦亡。然而,尚不清楚H2S如何通过 ceRNA 轴调节细胞焦亡。因此,我们建立了42H2S暴露的肉鸡模型以评估细胞焦亡并通过免疫组织化学和RNA测序获得ceRNA网络。我们检测到H2S诱导的细胞焦亡和通过双荧光素酶报告基因检测验证的 circRNA-IGLL1-17828/miR-6631-5p/DUSP6 轴。我们还测量了ROS水平和焦亡指标的表达,例如 (Caspase1) Casp-1、白细胞介素 1β (IL-1β) 和白介素 1β (IL-18)miR-6631-5p 敲低降低了H2S诱导的焦亡指标。miR-6631-5p 的过表达或 DUSP6 敲低刺激了 ROS 的产生并上调了焦亡指标。N-乙酰-L-半胱氨酸(NAC)降低了由 miR-6631-5p 诱导的细胞焦亡指标和 ROS 水平。此外,circRNA-IGLL1-17828作为DUSP6ceRNA参与了分子间竞争。总之,circRNA-IGLL1-17828/miR-6631-5p/DUSP6 串扰调节H2S通过产生ROS诱导的肉鸡气管细胞焦亡。这是首次揭示circRNA相关CeRNAH2S诱导的细胞焦亡的调控机制,为环境毒理学提供重要参考。

 

文献列表

序号

主要内容

论文标题

杂志

影响因子

单位

1

环状RNA circHIPK3通过降低miR-29b功能促进肠上皮稳态

Circular RNA circHIPK3 promotes homeostasis of the intestinal epithelium by reducing miR-29b function

Gastroenterology.

17.373

马里兰大学医学院等

2

circACTN4与FUBP1相互作用通过调节原癌基因MYC的表达促进乳腺癌的发生和进展

The circACTN4 interacts with FUBP1 to promote tumorigenesis and progression of breast cancer by regulating the expression of proto-oncogene MYC

Mol Cancer.

15.303

重庆医科大学等

3

硫化氢暴露通过circRNA-17828/miR-6631-5p/DUSP6串扰对ROS产生的调节作用诱导肉鸡气管焦亡

Hydrogen sulfide exposure induces pyroptosis in the trachea of broilers via the regulatory effect of circRNA-17828/miR-6631-5p/DUSP6 crosstalk on ROS production

J Hazard Mater.

9.036

东北农业大学等

4

心脏研究进展——从重启心脏再生到完整的心脏细胞图谱

Progress in cardiac research - from rebooting cardiac regeneration to a complete cell atlas of the heart

Cardiovasc Res.

8.168

马斯特里赫特大学等

5

CPSF4在肝细胞癌中调节circRNA形成和microRNA介导的基因沉默

CPSF4 regulates circRNA formation and microRNA mediated gene silencing in hepatocellular carcinoma

Oncogene.

7.971

中南大学等

6

肿瘤微环境中的相互作用协调肿瘤性 RNA 代谢和转录组多样性

Interplay within tumor microenvironment orchestrates neoplastic RNA metabolism and transcriptome diversity

Wiley Interdiscip Rev RNA.Review

6.913

博帕尔印度科学教育与研究学院等

7

CircC16orf62通过miR-138-5p/PTK2/AKT轴促进肝细胞癌进展

CircC16orf62 promotes hepatocellular carcinoma progression through the miR-138-5p/PTK2/AKT axis

Cell Death Dis.

6.303

贵州医科大学附属医院等

8

m(6)RNA 修饰及其在癌症特别是肺癌中的作用

m(6)A modification of RNA and its role in cancer, with a special focus on lung cancer

Genomics.Review

6.206

ICAR-印度兽医研究所等

9

circTmeff-1 在环境诱导的吗啡成瘾性中的作用

The role of circTmeff-1 in incubation of context-induced morphine craving

Pharmacol Res.

5.891

河北医科大学等

10

AQUARIUM:使用基于模型的策略准确量化环状RNA亚型

AQUARIUM: accurate quantification of circular isoforms using model-based strategy

Bioinformatics.

5.61

南京中医药大学等

11

重度抑郁症女性患者外周血单核细胞的诊断生物标志物 Hsa_circ_0126218 及其功能预测

Diagnostic Biomarker Hsa_circ_0126218 and Functioning Prediction in Peripheral Blood Monocular Cells of Female Patients With Major Depressive Disorder

Front Cell Dev Biol.

5.204

哈尔滨医科大学等

12

CircRNA DOCK1 调节 miR-409-3p/MCL1 轴以调节人脑血管平滑肌细胞的增殖和凋亡

CircRNA DOCK1 Regulates miR-409-3p/MCL1 Axis to Modulate Proliferation and Apoptosis of Human Brain Vascular Smooth Muscle Cells

Front Cell Dev Biol.

5.201

山西医科大学第三医院等

13

环状RNA作为宿主与病毒冲突的额外参与者

Circular RNA as an Additional Player in the Conflicts Between the Host and the Virus

Front Immunol.Review

5.087

印度(IISER)等

14

宿主非编码 RNA 在结核分枝杆菌感染中的作用

The Roles of Host Noncoding RNAs in Mycobacterium tuberculosis Infection

Front Immunol.Review

5.087

济宁医学院等

15

多组学整合揭示肝细胞癌中的关键环状 RNA

Multiple Omics Integration Reveals Key Circular RNAs in Hepatocellular Carcinoma

Front Oncol.

4.845

上海中山医院等

16

环状RNA在肺癌病理生物学中的新兴作用

Emerging role of circular RNAs in the pathobiology of lung cancer

Biomed Pharmacother.Review

4.545

伊朗Shahid Beheshti 医科大学等

17

环状RNA circFOXO3通过靶向miR-214调节KDM2A促进口腔鳞状细胞癌的肿瘤生长和转移

Circular RNA circFOXO3 regulates KDM2A by targeting miR-214 to promote tumor growth and metastasis in oral squamous cell carcinoma

J Cell Mol Med.

4.485

佛山口腔医院等

18

反义环状 RNA 调控拟南芥中 RuBisCO 小亚基基因的表达

An Antisense Circular RNA Regulates Expression of RuBisCO Small Subunit Genes in Arabidopsis

Front Plant Sci.

4.404

北京林业大学等

19

环状 RNA circDUS2 是颅内动脉瘤的潜在生物标志物

Circular RNA circDUS2 Is a Potential Biomarker for Intracranial Aneurysm

Front Aging Neurosci.

4.362

脑血管病转化医学等

20

环状RNAs和MicroRNAs在慢性鼻窦炎鼻息肉中的基因表达谱

Gene Expression Profiles of Circular RNAs and MicroRNAs in Chronic Rhinosinusitis With Nasal Polyps

Front Mol Biosci.

4.187

南昌大学第一附属医院等

21

外泌体circRNA作为多发性骨髓瘤相关心肌损伤的新潜在治疗靶点

Exosomal circRNA as a novel potential therapeutic target for multiple myeloma-related myocardial damage

Cancer Cell Int.

4.178

山东中医药大学附属医院等

22

环状RNA在儿童常见实体恶性肿瘤中的新作用

The emerging role of circular RNAs in common solid malignant tumors in children

Cancer Cell Int.Review

4.178

青岛大学妇女儿童医院等

23

CircRNA NALCN 作为 miR-493-3p 海绵调节 PTEN 表达并抑制胶质瘤进展

CircRNA NALCN acts as an miR-493-3p sponge to regulate PTEN expression and inhibit glioma progression

Cancer Cell Int.

4.178

中南大学湘雅医院等

24

环状 RNA PVT1 沉默通过靶向 microRNA-125b 和 microRNA-200a 防止大鼠缺血再灌注损伤

Circular RNA PVT1 silencing prevents ischemia-reperfusion injury in rat by targeting microRNA-125b and microRNA-200a

J Mol Cell Cardiol.

4.131

广西医科大学第一附属医院等

25

环状RNA在癌症中充当自噬的调节剂

Circular RNAs act as regulators of autophagy in cancer

Mol Ther Oncolytics.Review

4.116

青岛大学医学院等

26

癌相关成纤维细胞衍生的外泌体通过 miR-580-5p 在缺氧应激下通过外显子 circHIF1A 调节乳腺癌细胞干细胞

Carcinoma-associated fibroblasts derived exosomes modulate breast cancer cell stemness through exonic circHIF1A by miR-580-5p in hypoxic stress

Cell Death Discov.

4.11

复旦大学中山医院等

27

CircRNA-ceRNA 网络揭示 CircRNA 在阿尔茨海默病中的潜在调节作用涉及 cGMP-PKG 信号通路

CircRNA-ceRNA Network Revealing the Potential Regulatory Roles of CircRNA in Alzheimer's Disease Involved the cGMP-PKG Signal Pathway

Front Mol Neurosci.

4.057

山东理工大学等

28

外泌体环状 RNA RNA-seq 分析和外泌体 circ-CYP24A1 在皮肤鳞状细胞癌中的致癌作用

Exosomal Circular RNA RNA-seq Profiling and the Carcinogenic Role of Exosomal circ-CYP24A1 in Cutaneous Squamous Cell Carcinoma

Front Med (Lausanne).

3.902

中国医科大学第一医院等

29

丹酚酸B对肥胖小鼠棕色脂肪组织RNA表达及lncRNA共表达网络的影响

Effects of Salvianolic acid B on RNA expression and co-expression network of lncRNAs in brown adipose tissue of obese mice

J Ethnopharmacol.

3.693

北京中医药大学等

30

非编码 RNA 和细胞外载体:它们在妊娠期糖尿病发病机制中的作用

Non-Coding RNAs and Extracellular Vehicles: Their Role in the Pathogenesis of Gestational Diabetes Mellitus

Front Endocrinol (Lausanne).Review

3.641

盛京医院等

31

环状RNA hsa_circ_0032463通过调节miR-498/LEF1轴促进骨肉瘤发展

Circular RNA hsa_circ_0032463 acts as a tumor promoter in osteosarcoma by regulating miR-498/LEF1 axis

Mol Cell Biol.

3.612

郑州大学第一附属医院等

32

PGC相关ncRNA的鉴定及其与胃癌临床病理特征的关系

Identification of PGC-related ncRNAs and their relationship with the clinicopathological features of Gastric Cancer

J Cancer.

3.567

中国医科大学第一医院等

33

过表达的circRANBP17作为致癌基因通过miR-635/RUNX2轴促进鼻咽癌

Overexpressed circRANBP17 acts as an oncogene to facilitate nasopharyngeal carcinoma via the miR-635/RUNX2 axis

J Cancer.

3.567

郑州大学第一附属医院等

34

转基因糖尿病小鼠肾脏中的环状 RNA 表达谱

Circular RNA expression profile in transgenic diabetic mouse kidneys

Cell Mol Biol Lett.

3.454

广州医科大学附属顺德医院等

35

环状RNA circ_0001588吸附miR-211-5p通过上调YY1表达促进胶质母细胞瘤的进展

Circular RNA circ_0001588 sponges miR-211-5p to facilitate the progression of glioblastoma via up-regulating YY1 expression

J Gene Med.

3.257

中国医科大学附属肿瘤医院等

36

Circ-MFN2 通过调节 miR-574-3p/IGF1R 信号轴正向调节结直肠癌的增殖、转移和放射抗性

Circ-MFN2 Positively Regulates the Proliferation, Metastasis, and Radioresistance of Colorectal Cancer by Regulating the miR-574-3p/IGF1R Signaling Axis

Front Genet.

3.255

安徽医科大学第四附属医院等

37

耗竭circ_0136474并恢复miR-766-3p通过调节DNMT3A减轻IL-1β诱导的骨关节炎进展中的软骨细胞氧化损伤

Exhausting circ_0136474 and Restoring miR-766-3p Attenuate Chondrocyte Oxidative Injury in IL-1尾-Induced Osteoarthritis Progression Through Regulating DNMT3A

Front Genet.

3.255

武汉中南医院等

38

Hsa_circ_0042823 通过 miR-877-5p/FOXM1 轴加速喉鳞状细胞癌的癌症进展

Hsa_circ_0042823 accelerates cancer progression via miR-877-5p/FOXM1 axis in laryngeal squamous cell carcinoma

Ann Med.

3.24

河南省人民医院等

39

双矩阵预测circRNA-疾病关联

Double matrix completion for circRNA-disease association prediction

BMC Bioinformatics.

3.24

安徽大学等

40

茶叶斑病病原体Lasiodiplodia theobromae感染后茶叶中circRNA的功能注释

Functional Annotation of circRNAs in Tea Leaves after Infection by the Tea Leaf Spot Pathogen, Lasiodiplodia theobromae

Phytopathology.

3.232

贵州大学等

41

下调环状 RNA Prkcsh 抑制脊髓损伤后的炎症反应

Down-regulating Circular RNA Prkcsh suppresses the inflammatory response after spinal cord injury

Neural Regen Res.

3.171

济南市中心医院等

42

胃癌细胞来源的外泌体可通过诱导环状RNA-circ_0004303表达调控间充质干细胞的生物学功能

Gastric cancer cell-derived exosomes can regulate the biological functions of mesenchymal stem cells by inducing the expression of circular RNA circ_0004303

Stem Cells Dev.

3.084

北京协和医学院等

43

一种新鉴定的circ-ANKHD1靶向miR-27a-3p/SFRP1信号通路并调节颗粒细胞的凋亡

A novel identified circ-ANKHD1 targets the miR-27a-3p/SFRP1 signaling pathway and modulates the apoptosis of granulosa cells

Environ Sci Pollut Res Int.

3.056

华南农业大学等

44

环状RNA circ-FAM158A通过调节miR-138-5p/SLC7A5轴促进视网膜母细胞瘤进展

Circular RNA circ-FAM158A promotes retinoblastoma progression by regulating miR-138-5p/SLC7A5 axis

Exp Eye Res.

3.013

福建医科大学等

45

CircPRDM2 通过海绵吸附 miR-760 升高 EZH2 促进骨肉瘤的阿霉素耐药

CircPRDM2 Contributes to Doxorubicin Resistance of Osteosarcoma by Elevating EZH2 via Sponging miR-760

Cancer Manag Res.

2.888

天津协和医学等

46

葡萄籽原花青素 (GSP) 通过调节 hsa_circ_0070934/miR-136-5p/PRAF2 轴抑制皮肤鳞状细胞癌的发展

Grape Seed Proanthocyanidins (GSPs) Inhibit the Development of Cutaneous Squamous Cell Carcinoma by Regulating the hsa_circ_0070934/miR-136-5p/PRAF2 Axis

Cancer Manag Res.

2.888

江西省中西医结合医院等

47

circRNA-TBC1D4、circRNA-NAALAD2 和 circRNA-TGFBR3:神经母细胞瘤中选定的关键 circRNA 及其与临床特征的关联

circRNA-TBC1D4, circRNA-NAALAD2 and circRNA-TGFBR3: Selected Key circRNAs in Neuroblastoma and Their Associations with Clinical Features

Cancer Manag Res.

2.887

复旦大学附属儿童医院等

48

环状 RNA 在胰腺癌诊断和治疗中的潜在用途的最新进展

Recent Advances in the Potential Use of Circular RNA for the Diagnosis and Treatment of Pancreatic Cancer

Cancer Manag Res.Review

2.887

盛京医院等

49

Circ-HACE1 通过海绵吸附 miR-485-3p 调节 Toll 样受体 4 加重香烟烟雾提取物诱导的人支气管上皮细胞损伤

Circ-HACE1 Aggravates Cigarette Smoke Extract-Induced Injury in Human Bronchial Epithelial Cells via Regulating Toll-Like Receptor 4 by Sponging miR-485-3p

Int J Chron Obstruct Pulmon Dis.

2.77

安徽城市管理职业学院等

50

冠心病人外周血单个核细胞circRNAs表达特征

Characteristics of circular RNAs expression of peripheral blood mononuclear cells in humans with Coronary Artery Disease

Physiol Genomics.

2.745

南京医科大学等

51

环状RNA circLDB2作为竞争性内源性RNA抑制非鳞状非小细胞肺癌的发展并促进顺铂敏感性

Circular RNA circLDB2 functions as a competing endogenous RNA to suppress development and promote cisplatin sensitivity in non-squamous non-small cell lung cancer

Thorac Cancer.

2.612

郑州大学第一附属医院等

52

Circ_0091702海绵吸附miR-545-3p,通过上调 THBS2 减轻脓毒症相关的急性肾损伤

Circ_0091702 serves as a sponge of miR-545-3p to attenuate sepsis-related acute kidney injury by upregulating THBS2

J Mol Histol.

2.53

台州市第一人民医院等

53

通过全转录组测序在男性骨质疏松症患者中鉴定出关键环状 RNA

Key circular RNAs identified in male osteoporosis patients by whole transcriptome sequencing

PeerJ.

2.377

哈尔滨医科大学第二附属医院等

54

通过 RNA 测序表征高度转移性肝细胞癌细胞的细胞突起和细胞体的小 RNA 转录组

Characterization of the small RNA transcriptomes of cell protrusions and cell bodies of highly metastatic hepatocellular carcinoma cells via RNA sequencing

Oncol Lett.

2.312

温州医科大学等

55

软骨终板退变相关患者中差异表达的circRNA、miRNA和基因的鉴定

Identification of Differentially Expressed circRNAs, miRNAs, and Genes in Patients Associated with Cartilaginous Endplate Degeneration

Biomed Res Int.

2.279

天津医科大学等

56

氟西汀在脑缺血中的作用及氟西汀介导的环状RNA和信使RNA的鉴定中风

The functions of fluoxetine and identification of fluoxetine-mediated circular RNAs and messenger RNAs in cerebral ischemic stroke

Bioengineered.

2.206

深圳市人民医院等

57

CircRAB3B 抑制银屑病中 miR-1228-3p/PTEN 轴的调节,抑制增殖、运动、细胞周期进程并促进 IL-22 诱导的角质形成细胞的凋亡

CircRAB3B suppresses proliferation, motility, cell cycle progression and promotes the apoptosis of IL-22-induced keratinocytes depending on the regulation of miR-1228-3p/PTEN axis in psoriasis

Autoimmunity.

2.129

中国上海同济大学医学院等

58

Circ_0084615 是结直肠癌中的致癌环状 RNA,通过抑制 miR-599 促进 DNMT3A 表达

Circ_0084615 is an oncogenic circular RNA in colorectal cancer and promotes DNMT3A expression via repressing miR-599

Pathol Res Pract.

2.051

北京大学深圳医院等

59

2007-2018年全球环状RNA研究趋势文献计量分析

Bibliometric Analysis of Global Circular RNA Research Trends from 2007 to 2018

Cell J.

1.984

上海长海医院等

60

人椎间盘退变发病机制中的circ-RNA表达模式和circ-RNA-miRNA-mRNA网络

Circ-RNA Expression Pattern and circ-RNA-miRNA-mRNA Network in The Pathogenesis of Human Intervertebral Disc Degeneration

Cell J.

1.984

潍坊医科大学等

61

甲状腺乳头状癌circRPS28 (hsa_circ_0049055) 是的新贡献者通过作为 miR-345-5p 的 ceRNA 调节卷曲家族受体 8 (FZD8) 来调节细胞生长和运动

circRPS28 (hsa_circ_0049055) is a novel contributor for papillary thyroid carcinoma by regulating cell growth and motility via functioning as ceRNA for miR-345-5p to regulate frizzled family receptor 8 (FZD8)

Endocr J.

1.952

郑州市中心医院等

62

CircHACE1作为竞争性内源性RNA通过吸附miR-346上调Tfcp2L1来抑制分化的甲状腺癌进展

CircHACE1 functions as a competitive endogenous RNA to curb differentiated thyroid cancer progression by upregulating Tfcp2L1 through adsorbing miR-346

Endocr J.

1.951

泰州市人民医院等

63

环状RNA circLMF1通过调节miR-125a-3p/VEGFA或FGF1轴调控PDGF-BB诱导的人主动脉平滑肌细胞增殖和迁移

Circular RNA circLMF1 regulates PDGF-BB-induced proliferation and migration of human aortic smooth muscle cells by regulating the miR-125a-3p/VEGFA or FGF1 axis

Clin Hemorheol Microcirc.

1.743

青海省心脑血管病专科医院等

64

基于二代测序的癫痫小鼠海马中差异表达的circRNA和功能通路

Differentially expressed circRNA and functional pathways in the hippocampus of epileptic mice based on next-generation sequencing

Kaohsiung J Med Sci.

1.739

广西中医药大学等

65

circRNA 在癌症中的翻译作用

Translation role of circRNAs in cancers

J Clin Lab Anal.Review

1.543

宁波大学附属李惠丽医院等

66

circVAPA通过miR-132/HOXA7轴促进口腔癌细胞的增殖、迁移和侵袭

circVAPA promotes the proliferation, migration and invasion of oral cancer cells through the miR-132/HOXA7 axis

J Int Med Res.

1.285

武汉市第六医院等

67

综合分析揭示了阵发性和持续性房颤患者的必需 mRNA、长链非编码 RNA (lncRNA) 和环状 RNA (circRNA)

Integrative analysis reveals essential mRNA, long non-coding RNA (lncRNA), and circular RNA (circRNA) in paroxysmal and persistent atrial fibrillation patients

Anatol J Cardiol.

1.221

南京市第一附属医院等

68

circ-PTTG1IP/miR-671-5p/TLR4轴调节类风湿性关节炎成纤维细胞样滑膜细胞的增殖、迁移、侵袭和炎症反应

circ-PTTG1IP/miR-671-5p/TLR4 axis regulates proliferation, migration, invasion and inflammatory response of fibroblast-like synoviocytes in rheumatoid arthritis

Gen Physiol Biophys.

1.074

武汉中部战区总医院等

69

circ-CSPP1通过直接靶向 miR-431/LASP1 轴作为结直肠癌的有效驱动因素

Identification of circRNA circ-CSPP1 as a potent driver of colorectal cancer by directly targeting the miR-431/LASP1 axis

Open Life Sci.

0.693

天津市第三中心医院等

70

肿瘤来源的外泌体circFARSA通过PTEN/PI3K/AKT通路介导M2巨噬细胞极化促进非小细胞肺癌转移

Tumor-derived exosomal circFARSA mediates M2 macrophage polarization via the PTEN/PI3K/AKT pathway to promote non-small cell lung cancer metastasis

Cancer Treat Res Commun

0

苏州大学第一医院等

71

【环状RNA与肝病的关系】

[Relationship between circular RNA and liver disease]

Zhonghua Gan Zang Bing Za ZhiReview

0

天津医科大学第二医院等