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  • Catalog CircRNA Products
  • Product Introduction
  • Case Analysis

  • In recent years, a large number of circRNA molecules have been found to play biological roles through various pathways. The groundbreaking study of natural circRNAs as translational templates for direct translation of peptides or proteins has made it possible to use circRNAs as vectors to develop therapeutic drugs for diseases. Compared to linear RNAs such as mRNA, the closed-loop structure of circRNAs allows for a substantially longer half-life of their presence in the organism, and this stabilized structure is extremely advantageous for the sustained expression of functional proteins/peptides.


    Relying on more than 10 years of research and development and innovative exploration in the field of circRNA, Geneseed has established a circRNA stock solution  production system. We can provide catalog products of reporter gene, tumor antigen, anti-tumor, growth factor, immunotherapy, gene editing, protein/antibody replacement, iPSC reprogramming, anti-aging, neurotrophic factor, nerve regeneration transforming factor, natural circular RNA and other series. Our products are prepared by independent intellectual property technology, with good integrity and high purity. It can be used as a positive control for experimental exploration, translation and expression verification, transfection and delivery evaluation, process optimization to empower the next generation of RNA therapeutics.


    Transport and preservation

    Product dry ice transportation. -80℃ ultra-low temperature storage, can be stable storage for one year.


    Specification


    Product    Category

    Name

    Model

    Specification

    Reporter gene

    GSPure® Circ-eGFP

    R0701 / R0702 / R0703 / R0704

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-Fluc

    R0801 / R0802 / R0803 / R0804

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-mCherry

    R0901 / R0902 / R0903 / R0904

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-beta gal

    R1401 / R1402 / R1403 / R1404

    100 μg / 500 μg / 1 mg / 5 mg

    Tumor antigen

    GSPure® Circ-OVA

    R1501 / R1502 / R1503 / R1504

    100 μg / 500 μg / 1 mg / 5 mg

    Anti-tumor

    GSPure® Circ-TP53

    R1701 / R1702 / R1703 / R1704

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-Trp53

    R2501 / R2502 / R2503 / R2504

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-PTEN-L (homo)

    R1001 / R1002 / R1003 / R1004

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-PTEN-L (mmu)

    R1101 / R1102 / R1103 / R1104

    100 μg / 500 μg / 1 mg / 5 mg

    Growth factor

    GSPure® Circ-VEGFA165 (homo)

    R1201 / R1202 / R1203 / R1204

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-VEGFA165 (mmu)

    R1301 / R1302 / R1303 / R1304

    100 μg / 500 μg / 1 mg / 5 mg

    immunotherapy

    GSPure® Circ-IL2 (homo)

    R1901 / R1902 / R1903 / R1904

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-IL2 (mmu)

    R3201 / R3202 / R3203 / R3204

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-IL12a

    R3301 / R3302 / R3303 / R3304

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-IL12A

    R3401 / R3402 / R3403 / R3404

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-IL12B

    R3501 / R3502 / R3503 / R3504

    100 μg / 500 μg / 1 mg / 5 mg

    Gene editing

    GSPure® Circ-Cas9

    R2001 / R2002 / R2003 / R2004

    100 μg / 500 μg / 1 mg / 5 mg

    Protein/

    Antibody replacement

    GSPure® Circ-EPO (homo)

    R2101 / R2102 / R2103 / R2104

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-EPO (mmu)

    R2301 / R2302 / R2303 / R2304

    100 μg / 500 μg / 1 mg / 5 mg

    iPSC reprogramming

    GSPure® Circ-SOX2 (homo)

    R2201 / R2202 / R2203 / R2204

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-SOX2 (mmu)

    R2401 / R2402 / R2403 / R2404

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-OCT4 (homo)

    R2601 / R2602 / R2603 / R2604

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-OCT4 (mmu)

    R2701 / R2702 / R2703 / R2704

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-KLF4 (homo)

    R2801 / R2802 / R2803 / R2804

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-KLF4 (mmu)

    R2901 / R2902 / R2903 / R2904

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-C-Myc (homo)

    R3001 / R3002 / R3003 / R3004

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-C-Myc (mmu)

    R3101 / R3102 / R3103 / R3104

    100 μg / 500 μg / 1 mg / 5 mg

    Anti-aging

    GSPure® Circ-TERT

    R3601 / R3602 / R3603 / R3604

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-Tert

    R3701 / R3702 / R3703 / R3704

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-FGF21 (homo)

    R3801 / R3802 / R3803 / R3804

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-FGF21 (mmu)

    R3901 / R3902 / R3903 / R3904

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-αKlotho (homo)

    R4001 / R4002 / R4003 / R4004

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-αKlotho (mmu)

    R4101 / R4102 / R4103 / R4104

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-sTGFβR2 (homo)

    R4201 / R4202 / R4203 / R4204

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-sTGFβR2 (mmu)

    R4301 / R4302 / R4303 / R4304

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-FGF23 (homo)

    R4401 / R4402 / R4403 / R4404

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-FGF23 (mmu)

    R4501 / R4502 / R4503 / R4504

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-FGF17 (homo)

    R4601 / R4602 / R4603 / R4604

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-FGF17 (mmu)

    R4701 / R4702 / R4703 / R4704

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-SOX8 (homo)

    R4801 / R4802 / R4803 / R4804

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-SOX8 (mmu)

    R4901 / R4902 / R4903 / R4904

    100 μg / 500 μg / 1 mg / 5 mg

    Neurotrophic factor

    GSPure® Circ-NGF (homo)

    R5001 / R5002 / R5003 / R5004

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-NGF (mmu)

    R5101 / R5102 / R5103 / R5104

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-BDNF (homo)

    R5201 / R5202 / R5203 / R5204

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-BDNF (mmu)

    R5301 / R5302 / R5303 / R5304

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-GDNF (homo)

    R5401 / R5402 / R5403 / R5404

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-GDNF (mmu)

    R5501 / R5502 / R5503 / R5504

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-NT3 (homo)

    R5601 / R5602 / R5603 / R5604

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-NT3 (mmu)

    R5701 / R5702 / R5703 / R5704

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-NT4 (homo)

    R5801 / R5802 / R5803 / R5804

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-NT4 (mmu)

    R5901 / R5902 / R5903 / R5904

    100 μg / 500 μg / 1 mg / 5 mg

    Nerve regeneration

    transforming factor

    GSPure® Circ-NeuroD1 (homo)

    R6001 / R6002 / R6003 / R6004

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-NeuroD1 (mmu)

    R6101 / R6102 / R6103 / R6104

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-NeuroD2 (homo)

    R6201 / R6202 / R6203 / R6204

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-NeuroD2 (mmu)

    R6301 / R6302 / R6303 / R6304

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-NeuroD6 (homo)

    R6401 / R6402 / R6403 / R6404

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-NeuroD6 (mmu)

    R6501 / R6502 / R6503 / R6504

    100 μg / 500 μg / 1 mg / 5 mg

    Natural circular RNA

    GSPure® Circ-PVT1 (homo)

    R6601 / R6602 / R6603 / R6604

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-PVT1 (mmu)

    R6701 / R6702 / R6703 / R6704

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-FOXO3 (homo)

    R6801 / R6802 / R6803 / R6804

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-FOXO3 (mmu)

    R6901 / R6902 / R6903 / R6904

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-HIPK3

    R7001 / R7002 / R7003 / R7004

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-ZNF609

    R7101 / R7102 / R7103 / R7104

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-ZFR

    R7201 / R7202 / R7203 / R7204

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-SMARCA5

    R7301 / R7302 / R7303 / R7304

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-PRKCI

    R7401 / R7402 / R7403 / R7404

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-NRIP1

    R7501 / R7502 / R7503 / R7504

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-ABCB10

    R7601 / R7602 / R7603 / R7604

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-CDYL

    R7701 / R7702 / R7703 / R7704

    100 μg / 500 μg / 1 mg / 5 mg

    GSPure® Circ-Mbl

    R7801 / R7802 / R7803 / R7804

    100 μg / 500 μg / 1 mg / 5 mg



  • High integrity


    Figure 1: GSPure® Circ-eGFP (left) and GSPure® Circ-mCherry (right) integrity (CE) > 95% after purification




    High purity


    Figure 2: GSPure® Circ-eGFP (left) and GSPure® Circ-Fluc (right) purity (HPLC) > 95% after purification



    High quality


    Fig 3: Fluorescence detection results after GSPure®Circ-eGFP transfected 293T cells, magnification: 100×. 






    Fig 4: Fluorescence detection results after GSPure® Circ-mCherry transfected 293T cells, magnification: 100×. 




    Fig 5: Results of luciferase detection after GSPure® Circ-Fluc transfection of 293T cells.